Hope propels us into the future
WELCOME TO fundación LIBELLAS
Fundación Libellas is an international, nonprofit patient advocacy organization dedicated to improving the lives of children affected by NALCN ion channel-related diseases, through research, family support programs and education.
To provide support and funding for research focused on NALCN-related diseases.
To promote advocacy for families and patients with diseases related to the NALCN ion channel mutations.
To be a link between patients, doctors and researchers.
We aim to create an international network of patients, physicians and researchers who work together to transform the lives of those living with severe neurodevelopmental disorders induced by NALCN mutations.
ION CHANNELS: Ion channels are integral membrane proteins that allow specific ions to passively pass through lipid membranes following the electrochemical gradient for the permeant ions. They are crucial components of cellular excitabilitity and are involved in many human diseases.
NALCN is a highly conserved ion channel across species and is involved in cell excitability of neurons. Mutations of NALCN are involved in ultra-rare and severe genetic diseases.
The brain uses electrical signals to control essentially every aspect of our life: from breathing and walking to speaking and intellectual reasoning.
NALCN channel, predominantly expressed in neurons, regulates the resting membrane potential and neuronal excitability.